Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia
Identifieur interne : 007F75 ( Main/Exploration ); précédent : 007F74; suivant : 007F76Impact of two rounds of mass drug administration using diethylcarbamazine combined with albendazole on the prevalence of Brugia timori and of intestinal helminths on Alor Island, Indonesia
Auteurs : Tim Oqueka [Allemagne] ; Taniawati Supali [Indonésie] ; Is Suhariah Ismid [Indonésie] ; Paul Rückert [Indonésie] ; Mark Bradley [Royaume-Uni] ; Peter Fischer [Allemagne, États-Unis]Source :
- Filaria Journal [ 1475-2883 ] ; 2005.
Abstract
Annual mass drug administration (MDA) using diethylcarbamizine (DEC, 6 mg/kg) combined with albendazole (alb, 400 mg) is recommended by the Global Programme to Eliminate Lymphatic Filariasis (GPELF). This strategy has been shown to be efficient in the of control bancroftian filariasis, but data on brugian filariasis as well as on the positive side effects on intestinal helminths are lacking.
The effect of one selective treatment and two rounds of MDA using DEC and alb on the prevalence and intensity of
In all, the mf-rate dropped from 26.8% before any treatment to 3.8% following the second MDA. Almost all mf-positive, treated individuals showed very low mf densities. The crude prevalence of hookworm dropped from 25.3% to 5.9%. The reduction of prevalence of
The MDA using DEC and alb as recommended by GPELF is extremely effective for areas with brugian filariasis. The beneficial effect of MDA on intestinal helminths may strengthen the national programme to eliminate lymphatic filariasis in Indonesia and may set resources free which are otherwise used for deworming campaigns of schoolchildren.
Url:
DOI: 10.1186/1475-2883-4-5
PubMed: 16014169
PubMed Central: 1201159
Affiliations:
- Allemagne, Indonésie, Royaume-Uni, États-Unis
- Missouri (État)
- Saint-Louis (Missouri)
- École de médecine (Université Washington de Saint-Louis)
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Le document en format XML
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Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg</wicri:regionArea><wicri:noRegion>20359 Hamburg</wicri:noRegion><wicri:noRegion>20359 Hamburg</wicri:noRegion><wicri:noRegion>D-20359 Hamburg</wicri:noRegion></affiliation></author><author><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Parasitology, Faculty of Medicine, University of Indonesia, Salemba 6, Jakarta 10430, Indonesia</nlm:aff><country xml:lang="fr">Indonésie</country><wicri:regionArea>Department of Parasitology, Faculty of Medicine, University of Indonesia, Salemba 6, Jakarta 10430</wicri:regionArea><wicri:noRegion>Jakarta 10430</wicri:noRegion></affiliation></author><author><name sortKey="Ismid, Is Suhariah" sort="Ismid, Is Suhariah" uniqKey="Ismid I" first="Is Suhariah" last="Ismid">Is Suhariah Ismid</name><affiliation wicri:level="1"><nlm:aff 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wicri:level="1"><nlm:aff id="I5">Global Community Partnerships, GlaxoSmithKline, 980 Great West Road, Brentfort Middlesex TW8 9GS, U.K</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Global Community Partnerships, GlaxoSmithKline, 980 Great West Road, Brentfort Middlesex TW8 9GS</wicri:regionArea><wicri:noRegion>Brentfort Middlesex TW8 9GS</wicri:noRegion></affiliation></author><author><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name><affiliation wicri:level="1"><nlm:aff id="I1">Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg</wicri:regionArea><wicri:noRegion>20359 Hamburg</wicri:noRegion><wicri:noRegion>20359 Hamburg</wicri:noRegion><wicri:noRegion>D-20359 Hamburg</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="I6">Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 S. Euclid, Campus box 8051, St. Louis, MO 63110, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 S. Euclid, Campus box 8051, St. Louis, MO 63110</wicri:regionArea><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName><placeName><settlement type="city">Saint-Louis (Missouri)</settlement><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">Filaria Journal</title><idno type="eISSN">1475-2883</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Annual mass drug administration (MDA) using diethylcarbamizine (DEC, 6 mg/kg) combined with albendazole (alb, 400 mg) is recommended by the Global Programme to Eliminate Lymphatic Filariasis (GPELF). This strategy has been shown to be efficient in the of control bancroftian filariasis, but data on brugian filariasis as well as on the positive side effects on intestinal helminths are lacking.</p></sec><sec sec-type="methods"><title>Methods</title><p>The effect of one selective treatment and two rounds of MDA using DEC and alb on the prevalence and intensity of <italic>Brugia timori </italic>infection were studied on Alor island using a cross-sectional and a cohort approach. Before the campaign and ten months after each treatment cycle microfilariae (mf) were assessed by filtration of night blood. Before and ten months after MDA, stool samples were collected and the prevalence of intestinal helminths were determined.</p></sec><sec><title>Results</title><p>In all, the mf-rate dropped from 26.8% before any treatment to 3.8% following the second MDA. Almost all mf-positive, treated individuals showed very low mf densities. The crude prevalence of hookworm dropped from 25.3% to 5.9%. The reduction of prevalence of <italic>Ascaris lumbricoides </italic>(32.3% to 27.6%) and <italic>Trichuris trichiura </italic>(9.4% to 8.9%) was less pronounced. Within a cohort of 226 individuals, which was examined annually, the prevalence of <italic>A. lumbricoides </italic>dropped from 43.8% to 26.5% and of <italic>T. trichiura </italic>from 12.8% to 6.6%. The results indicate that this MDA approach reduces not only the mf prevalence of <italic>B. timori </italic>but also the prevalence of hookworm and to a lesser extent also of <italic>A. lumbricoides </italic>and <italic>T. trichiura</italic>.</p></sec><sec><title>Conclusion</title><p>The MDA using DEC and alb as recommended by GPELF is extremely effective for areas with brugian filariasis. The beneficial effect of MDA on intestinal helminths may strengthen the national programme to eliminate lymphatic filariasis in Indonesia and may set resources free which are otherwise used for deworming campaigns of schoolchildren.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Indonésie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Missouri (État)</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Oqueka, Tim" sort="Oqueka, Tim" uniqKey="Oqueka T" first="Tim" last="Oqueka">Tim Oqueka</name></noRegion><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></country><country name="Indonésie"><noRegion><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></noRegion><name sortKey="Ismid, Is Suhariah" sort="Ismid, Is Suhariah" uniqKey="Ismid I" first="Is Suhariah" last="Ismid">Is Suhariah Ismid</name><name sortKey="Ruckert, Paul" sort="Ruckert, Paul" uniqKey="Ruckert P" first="Paul" last="Rückert">Paul Rückert</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Bradley, Mark" sort="Bradley, Mark" uniqKey="Bradley M" first="Mark" last="Bradley">Mark Bradley</name></noRegion></country><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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